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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically described as focusing on practical aspects of study design which include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. A high degree of heterogeneity, however can result in problems with the trial design.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be a great way to identify the cause-effect relationship between an intervention and its results. However, they should not be used to replace explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study that includes the recruitment, design, and 프라그마틱 플레이; bookmarkpagerank.Com, delivery of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.