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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of study design, including the recruitment process and consent as well as adherence to the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from various geographical areas. This type of heterogeneity which is essential for a pragmatic trial to be valid and reduce bias in results, is also necessary. However too much heterogeneity could result in issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be a great way to identify the causality between an intervention and its results. They should not, however be used to replace explanation studies.

The pragmatism idea is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, 프라그마틱 슬롯 추천 which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes the recruitment, design, and delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary care settings.