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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also reduces bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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Pragmatic Play is renowned for its top-quality games and for offering an exceptional user experience. Its software is designed to work with mobile devices and is compatible with various languages. It has been recognized as one of the top casino gaming platforms despite its relative youth. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically requested by practitioners and policymakers in order to inform their decisions. They can also be a great method to determine the cause-effect relationship between an intervention and its outcomes. They should not, however be used to replace explanatory studies.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, and 프라그마틱 정품 pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study that includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.