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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically described as focusing on practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from various geographical areas. This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can lead to problems with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causal relationship between an intervention and its effects. However, they should not be used as a substitute for explanation trials.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a pragmatic study that include the recruitment process, the design and implementation of the intervention, as well as follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), 무료슬롯 프라그마틱 returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatics. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.