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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for 프라그마틱 a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity could cause issues with the trial design.

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Legality

Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. The software is available on mobile devices as well as in various languages. Despite its relative youth it has established itself as a leading casino gaming platform. Wolves is one of the latest games which is a five-reel slot machine with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They are also a good method of determining the causality between an intervention and its results. However, they shouldn't be used as a substitute for explanatory studies.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial that include the recruitment process, the design and delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.