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Pragmatic trials are those that are designed to inform real-world clinical practice. They are often focused on the practical aspects of the study design, including recruitment and consent in adherence, as well as the use of routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographic areas. This kind of heterogeneity is required for practical trials to be valid and reduces bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.
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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. The company is licensed by various regulatory bodies which include Malta Gaming Authority and UK Gambling Commission. The games are supported by top-of-the-line encryption technology and the security team is on hand to help players resolve any issues they may have.
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Legality
Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. The software is available on mobile devices and in multiple languages. It has established itself as one of the leading casino gaming platforms despite its relative infancy. The most recent releases include Wolves 5 reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policymakers to inform their decisions. They can also be a great way to identify the causality between an intervention and its outcomes. However, they should not, be used to replace the need for explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study, including recruitment, design, delivery of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.