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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of design, including recruitment and consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographical regions. This kind of heterogeneity is necessary for pragmatic trials to be valid and reduces bias in the results. However too much heterogeneity could cause problems with the design of the trial.

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Pragmatic Play has earned a reputation for providing high-quality games and a superior user experience. Its software is accessible on mobile devices and in multiple languages. It has established itself as one of the most popular casino gaming platforms despite its relative youth. Wolves is one of the latest games which is a five-reel slot machine that has a high RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be a great method of determining the causality between the intervention and its effects. However, they shouldn't be used in lieu for explanation trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis and pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary care settings.