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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, such as the recruitment process and consent in adherence, as well as the use of routinely available equipment.
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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for 프라그마틱 슬롯 무료 practical trials to be valid, and it also helps reduce the chance of bias in the results. However too much heterogeneity could lead to issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They can be used to determine the cause-effect relationship of an intervention and its effects. They should, however, not be used to replace explanation studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study which includes recruitment, design, 무료 프라그마틱 implementation of the intervention, and follow-up.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.