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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of designing a study that include recruitment and consent, adherence and the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity could cause issues with the trial design.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used in lieu for explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, 프라그마틱 슬롯버프 which support a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic trial which includes recruitment, design and delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority were conducted in primary-care settings.