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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of design that include the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographical regions. This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However too much heterogeneity could cause issues with the design of the trial.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be used to assess the causality of an intervention and its effects. However, they should not be used in lieu for explanation trials.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also proposed a framework for 무료슬롯 프라그마틱 프라그마틱 무료 슬롯버프체험 (visit the following page) pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as the follow-up.
There is a positive increase in the number of pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.