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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, such as the recruitment and consent process as well as adherence to the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographic areas. This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps to reduce the chance of bias in the results. Too much heterogeneity, however, can cause problems with the trial design.

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Legality

Pragmatic Play is renowned for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports multiple languages. Despite its infancy it has established itself as a top casino gaming platform. The latest releases include Wolves which is a five-reel video slot that has a healthy RTP and 프라그마틱 슬롯 체험 stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its effects. However, they should not be used as a substitute for explanatory studies.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study that includes recruitment, design, delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.