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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This type of heterogeneity which is vital for pragmatic trials to be valid and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however can result in problems with the design of the trial.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. Usually, they are ordered by policymakers and practitioners to help inform their decisions. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they should not be used to substitute for explanatory trials.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis and 프라그마틱 무료게임 무료체험 메타 [you could try this out] pragmatic trials, which inform policy and practice decisions. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a practical trial that include the recruitment process, the design and implementation of the intervention, as well as the follow-up.
There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.