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Pragmatic trials are studies designed to inform real-world clinical practice. They are often described as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Pragmatic is a software company that provides a variety of casino games available on online gambling platforms. Pragmatic's iGaming solutions are used by the top operators and casinos with a physical location. The company provides front-end design tools, analysis, marketing, promotions and payment systems, as well as security, customer support and bug reporting. The company also offers a safe environment with high-quality graphics, gaming and security.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be valid and also helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play, a major player on the live casino market offers a variety of classic table games like Blackjack and Roulette. The live studios of the company in Romania and Malta offer customers an authentic gaming experience as well a full range of virtual betting options. The company has also created several interactive game shows to make online gambling fun. Some of these shows are telecast live, while others feature famous personalities in the industry.

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Pragmatic Play offers not only mobile-friendly slot machines but also live casino and table games. The company is licensed by various regulatory bodies which include Malta Gaming Authority and UK Gambling Commission. The games are supported by top-of-the-line encryption technology, and the company's security team is always available to assist players solve any issues they may have.

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Legality

Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software can be used on mobile devices as well as in various languages. Despite its relative youth it has already established itself as a premier gaming platform for casinos. Its latest releases include Wolves 5 reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by policymakers and practitioners to help guide their decisions. They also provide a useful way to identify the causal relationship between the intervention and its effects. However, they shouldn't be used to substitute for explanatory trials.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.

There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.