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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include recruitment and consent, adherence and the use routinely available equipment.

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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be valid and reduce bias in results, is also necessary. Too much heterogeneity, however could cause issues with the trial design.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policymakers and practitioners to help guide their decisions. They can be used to determine the causal relationship between an intervention and its effects. However, 프라그마틱 슬롯 환수율 they shouldn't be used in lieu for the use of explanation trials.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as monitoring.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to note, however, that the majority of studies were conducted in primary-care settings.